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The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives

机译：血清素转运蛋白基因型与选择性5-羟色胺再摄取抑制剂（ssRI）相关的性副作用的关联：与口服避孕药的可能关系

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Objective To study the relationship between functional variants in the serotonin transporter gene ( SLC6A4 ) and selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction. Methods One hundred fifteen subjects aged 18–40 years and currently being treated with an SSRI for depression were assessed for clinical variables known to affect sexual well-being. SSRI-associated sexual difficulties were assessed with the Changes in Sexual Functioning Questionnaire (CSFQ). Subjects were subsequently genotyped for the SLC6A4 promoter region (5HTTLPR) insertion/deletion variant and a variable number of tandem repeats (VNTR) in the second intron. Results The 5HTTLPR insertion/deletion variant was associated with sexual dysfunction in this study sample [odds ratio (OR) = 2.7; 95% confidence interval (CI) 1.2, 6.4; p  = 0.02]. The relationship between promoter genotypes and sexual well-being differed in males and females and was related to whether females were taking an oral contraceptive (OC) medication. Females with the ll genotype were nearly eight times more likely to be categorized as having sexual dysfunction if they were taking OCs, while no relationship was observed in those not taking OCs. Conclusions These results suggest that a functional variant in the serotonin transporter gene is associated with sexual difficulties in persons taking an SSRI for depression. This relationship may differ by sex and be dependent on OC status in females. Copyright © 2009 John Wiley & Sons, Ltd.
机译：目的研究5-羟色胺转运蛋白基因（SLC6A4）的功能变异与选择性5-羟色胺再摄取抑制剂（SSRI）相关的性功能障碍之间的关系。方法对115名年龄在18至40岁且目前正在接受SSRI治疗抑郁症的受试者进行评估，了解其已知会影响性健康的临床变量。与SSRI相关的性困难通过“性功能问卷调查”（CSFQ）进行评估。随后对受试者的SLC6A4启动子区域（5HTTLPR）插入/缺失变体和第二个内含子中可变数目的串联重复序列（VNTR）进行基因分型。结果在该研究样本中，5HTTLPR插入/缺失变异与性功能障碍相关[比值比（OR）= 2.7； 95％置信区间（CI）1.2、6.4； p ＝ 0.02]。男性和女性中启动子基因型与性健康之间的关系不同，并且与女性是否服用口服避孕药有关。患有ll基因型的女性如果服用OC，被分类为性功能障碍的几率高近八倍，而未服用OC的女性则没有相关性。结论这些结果表明，5-羟色胺转运蛋白基因的功能性变异与服用SSRI治疗抑郁症的人的性障碍有关。这种关系可能因性别而异，并且取决于女性的OC状态。版权所有©2009 John Wiley＆Sons，Ltd.

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